Pharmacotherapy of Essential Tremor
نویسندگان
چکیده
منابع مشابه
Pharmacotherapy of Essential Tremor
Essential tremor (ET) is a common movement disorder but its pathogenesis remains poorly understood. This has limited the development of effective pharmacotherapy. The current therapeutic armamentaria for ET represent the product of careful clinical observation rather than targeted molecular modeling. Here we review their pharmacokinetics, metabolism, dosing, and adverse effect profiles and prop...
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BACKGROUND The pathophysiology of essential tremor, especially at the cellular level, is poorly understood. Although no drug has been specifically designed to treat essential tremor, several medications improve tremor, and others worsen it. Studying the mechanism of actions of these medications can help our understanding of tremor pathophysiology and contribute to future rational drug design. ...
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Background Essential tremor (ET) is among the most common neurological diseases and it often runs in families. How knowledgeable ET patients and their families are about their disease has been the subject of surprisingly little scholarship. Methods To fill this gap in knowledge, we administered a comprehensive 32-item survey (i.e., questions about etiology, pathophysiology, symptoms and signs...
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Methods Seventy-two patients with severe, medication-refractory essential tremor have been enrolled across seven international centers. Standard assessments of tremor severity and disability will be obtained before and after the procedure. Patients are randomized in a one-to-three fashion to receive either sham procedure or MR-guided focused ultrasound thalamotomy. The Tremor Research Group, ne...
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To broadly sample ET in different settings, we selected cases from three settings: a tertiaryreferral center (largest sample),5 a population-based study in Manhattan,6 and a brain repository.7 As expected, cases differed in several respects (Table). Using the same clinical questionnaire, each case was asked whether he/she sometimes has a head tremor. A 20 minute videotaped tremor examination wa...
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ژورنال
عنوان ژورنال: Journal of Central Nervous System Disease
سال: 2013
ISSN: 1179-5735,1179-5735
DOI: 10.4137/jcnsd.s6561